For immunochemical detection of PGIS
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Prostaglandin I Synthase (mouse) Polyclonal Antibody

Item No. 100023

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGI Synthase
  • PGIS
  • Prostacyclin Synthase
Immunogen
Synthetic peptide from the C-terminal region of mouse PGIS
Formulation (Request formulation change)
500 µl of Peptide affinity-purified polyclonal antibody.
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IHC, WB
Species Reactivity
(+) Mouse(+) Rat(+) Bovine(+) Ovine
UniProt Accession №
O35074
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    PGIS catalyzes the isomerization of PGH2 to PGI2. PGI2 (prostacyclin) is a potent vasodilator and inhibitor of platelet aggregation. PGIS is a membrane-bound hemoprotein localized primarily in endothelial cells.1 The cloned bovine and human enzymes contain 500 amino acids and a calculated molecular mass of 56,629 and 57,103, respectively.2,3,4 Northern blot analysis reveals that the mRNA for PGIS is expressed in a wide variety of human tissues and is particularly abundant in ovary, heart, skeletal muscle, lung, and prostate.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DeWitt, D.L., and Smith, W.L. Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein. The Journal of Biological Chemisty 258(5), 3285-3293 (1983).

    2. Miyata, A., Hara, S., Yokoyama, C., et al. Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200(3), 1728-1734 (1994).

    3. Pereira, B., Wu, K.K., and Wang, L.H. Molecular cloning and characterization of bovine prostacyclin synthase. Biochem. Biophys. Res. Commun. 203(1), 59-66 (1994).

    4. Hara, S., Miyata, A., Yokoyama, C., et al. Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. The Journal of Biological Chemisty 269(31), 19897-19903 (1994).

    Product Citations

    Ray, J.W., Sun, X., Cruz-Diaz, N., et al. Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague-Dawley rats. Physiol. Rep. 13(7), e70250 (2025).

    Chen, S.-T., Shi, W.-W., Lin, Y.-Q., et al. Embryo-derive TNF promotes decidualization via fibroblast activation. Elife 12, e82970 (2023).

    Seta, F., Rahmani, M., Turner, P.V., et al. Pulmonary oxidative stress is increased in cyclooxygenase-2- knockdown mice with mild pulmonary hypertension induced by monocrotaline. PLoS One 6(8), e23439 (2011).