An activator of caspases
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Apoptosis Activator 2

Item No. 10004176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione
CAS Number
79183-19-0
Synonyms
  • AAII
  • N-(3,4-dichlorobenzyl) Isatin
Molecular Formula
C15H9Cl2NO2
Formula Weight
306.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.25 mg/mlEthanol: 1 mg/ml
λmax
245, 296 nm
SMILES
O=C1C(C2=CC=CC=C2N1CC3=CC=C(Cl)C(Cl)=C3)=O
InChi Code
InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChi Key
KGRJPLRFGLMQMV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $40

    Add

    10 mg

    $73

    Add

    25 mg

    $171

    Add

    50 mg

    $302

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.1 This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, J.T., and Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc. Natl. Acad. Sci. USA 100(13), 7533-7538 (2003).