An activator of caspases
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Apoptosis Activator 2

Item No. 10004176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione
CAS Number
79183-19-0
Synonyms
  • AAII
  • N-(3,4-dichlorobenzyl) Isatin
Molecular Formula
C15H9Cl2NO2
Formula Weight
306.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.25 mg/mlEthanol: 1 mg/ml
λmax
245, 296 nm
SMILES
O=C1C(C2=CC=CC=C2N1CC3=CC=C(Cl)C(Cl)=C3)=O
InChi Code
InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChi Key
KGRJPLRFGLMQMV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $73

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    25 mg

    $171

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    50 mg

    $302

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    Cayman Chemical
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    Product Description

    Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.1 This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, J.T., and Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc. Natl. Acad. Sci. USA 100(13), 7533-7538 (2003).