An antimitotic resveratrol analog
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3,4',5-Trismethoxybenzophenone

Item No. 10004185

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,5-dimethoxyphenyl)(4-methoxyphenyl)-methanone
CAS Number
94709-12-3
Molecular Formula
C16H16O4
Formula Weight
272.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:3): 0.1 mg/mlDMSO: 20 mg/ml
λmax
222, 290 nm
SMILES
COc1ccc(cc1)C(=O)c1cc(OC)cc(OC)c1
InChi Code
InChI=1S/C16H16O4/c1-18-13-6-4-11(5-7-13)16(17)12-8-14(19-2)10-15(9-12)20-3/h4-10H,1-3H3
InChi Key
ZICXUWQPVOZNHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $38

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    25 mg

    $87

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    50 mg

    $165

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    100 mg

    $291

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    Cayman Chemical
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    Product Description

    Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.1 When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced.2 3,4',5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It inhibits the growth of a variety of human tumor cell lines at concentrations from 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br. J. Pharmacol. 123(8), 1691-1699 (1998).

    2. Nam, K.A., Kim, S., Heo, Y.H., et al. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch. Pharm. Res. 24(5), 441-445 (2001).

    3. Pettit, G.R., Grealish, M.P., Jung, M.K., et al. Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. J. Med. Chem. 45(12), 2534-2542 (2002).