A mixture of belinostat isomers
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Isomer(s)
34084Belinostat
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(E/Z)-Belinostat

Item No. 10004279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
CAS Number
414864-00-9
Synonyms
  • (E/Z)-PX 105684
  • (E/Z)-PXD 101
Molecular Formula
C15H14N2O4S
Formula Weight
318.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:5): 0.5 mg/ml
λmax
219, 268 nm
SMILES
O=S(N([H])C1=CC=CC=C1)(C2=CC(/C=C/C(N([H])O)=O)=CC=C2)=O
InChi Code
InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
InChi Key
NCNRHFGMJRPRSK-MDZDMXLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $38

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    50 mg

    $149

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    100 mg

    $223

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    250 mg

    $417

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    Product Description

    (E/Z)-Belinostat is a mixture of (E)-belinostat (Item No. 34084) and (Z)-belinostat.1,2 (E)-Belinostat is an inhibitor of class I and II histone deacetylases (HDACs) and reduces proliferation in a variety of cancer cell lines in vitro and in vivo.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, N., Jeffers, M., Kumar, S., et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem. J. 409(2), 581-589 (2008).

    2. Plumb, J.A., Finn, P.W., Williams, R.J., et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol. Cancer Ther. 2(8), 721-728 (2003).