For immunochemical detection of L-PGDS
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Prostaglandin D Synthase (lipocalin-type; mouse) Polyclonal Antibody

Item No. 10004344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • L-PGDS
  • Lipocalin-PGDS
Immunogen
Mouse recombinant L-PGDS
Formulation (Request formulation change)
500 µl of lyophilized protein A-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, when reconstituted in 500 µl double distilled water
Host
Rabbit
Applications
IHC, WB
Species Reactivity
(+) Human(+) Mouse
UniProt Accession №
O09114
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 ea (500 µl)

    $347

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin type enzyme (β-trace) and the hematopoietic enzyme.1,2 Lipocalin-type PGDS (L-PGDS) is localized in the central nervous system, genital organs of various mammals and the human heart.1,3,4,5 Patients with chronic renal failure and hypertension exhibit elevated amounts of L-PGDS in serum and urine.6 The L-PGD synthase has been identified as β-trace, which is a major protein in the human cerebrospinal fluid.2,7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eulitz, K., Yurawecz, M.P., Sehat, N., et al. Preparation, separation, and confirmation of the eight geometrical cis/trans conjugated linoleic acid isomers 8,10- through 11,13-18:2. Lipids 34(8), 873-877 (1999).

    2. Toh, H., Kubodera, H., Nakajima, N., et al. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Eng. 9(12), 1067-1082 (1996).

    3. Tokugawa, Y., Kunishige, I., Kuboto, Y., et al. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biol. Reprod. 58(2), 600-607 (1998).

    4. Melegos, D.N., Diamandis, E.P., Oda, H., et al. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clin. Chem. 42(12), 1984-1991 (1996).

    5. Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur. J. Biochem. 267(11), 3315-3322 (2000).

    6. Hirawa, N., Uehara, Y., Yamakado, M., et al. Lipocalin-type prostaglandin D synthase in essential hypertension. Hypertension 39 (part 2), 449-454 (2002).

    7. Zahn, M., Mäder, A., Schmidt, B., et al. Purification and N-terminal sequence of β-trace, a protein abundant in human cerebrospinal fluid. Neurosci. Lett. 154(1-2), 93-95 (1993).