For immunochemical detection of mPGES-1
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Prostaglandin E Synthase-1 (microsomal) Monoclonal Antibody (Clone 6C6)

Item No. 10004350

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Membrane-Associated PGES-1
  • MGST1-L1
  • mPGE Synthase-1
  • mPGES-1
  • PIG12
  • Prostaglandin H/E Isomerase
Immunogen
Recombinant human mPGE synthase-1
Clone Designation
6C6
Formulation (Request formulation change)
300 µg of protein G-affinity purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG1
Applications
WB
Species Reactivity
(+) Human(-) Ovine
UniProt Accession №
O14684
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (300 µg)

    $347

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    Product Description

    Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 PGES-1 is a 16 kDa membrane associated protein with glutathione-dependent activity.5,6 The mRNA for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine as well as in A549 and HeLa cells. PGES-1 protein expression is increased in A549 cells following treatment with IL-1β.5 Cayman’s PGE Synthase-1 (microsomal) Monoclonal Antibody (Clone 6C6) can be used for Western blot applications. The antibody recognizes PGE Synthase-1 (microsomal) at 16 kDa from human and ovine samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3(3), 353-357 (1973).

    2. Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am. J. Obstet. Gynecol. 171(4), 1092-1096 (1994).

    3. Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70(3), 359-370 (1976).

    4. Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34(16), 5604-5609 (1995).

    5. Jakobsson, P.J., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. USA 96(13), 7220-7225 (1999).

    6. Urade, Y., Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. J. Lipid Mediat. Cell Signal. 12(2-3), 257-273 (1995).

    Product Citations

    Lazarus, M., Kubata, B.K., Eguchi, N., et al. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Arch. Biochem. Biophys. 397(2), 336-341 (2002).