For immunochemical detection of LPA3
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LPA3 Polyclonal Antibody

Item No. 10004840

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • EDG-7
  • Lysophosphatidic Acid Receptor 3
Immunogen
Synthetic peptide from the N-terminal region of mouse protein LPA3
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide
Host
Rabbit
Applications
ICC, IF, and WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
Q9UBY5
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Lysophosphatidic acid receptor 3 (LPA3, also known as EDG-7) is one of three LPA receptors (LPA1, LPA2, and LPA3) that are members of large family of G protein-coupled receptors that also include those for sphingosine-1-phosphate (S1P1-5).1 The LPA receptors mediate many cellular responses including cytoskeletal rearrangements, cell proliferation, and inhibition of gap junction communication.2,3 Mouse and human LPA3 have 353 amino acids with an estimated molecular weight of 40 kDa.4,5 The mRNA level of LPA3 is high in testes, kidney, and lung but low in intestine, heart, thymus, and stomach.5 Cayman Chemical’s LPA3 polyclonal antibody can be used for western blot, immunofluorescence, and immunocytochemical analysis for LPA3 on samples of human, mouse, and rat origin. Cayman’s LPA3 Polyclonal Antibody detects a protein at around 40 kDa in human HepG2 cells, mouse macrophages, and in mouse and rat liver.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54(2), 265-269 (2002).

    2. Fukushima, N., and Chun, J. The LPA receptors. Prostaglandins Other Lipid Mediat. 64, 21-32 (2001).

    3. Contos, J.J.A., Ishii, I., and Chun, J. Lysophosphatidic Acid Receptors. Mol. Pharmacol. 58, 1188-1196 (2000).

    4. Bandoh, K., Aoki, J., Hosono, H., et al. Molecular cloning and characteristics of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. The Journal of Biological Chemisty 274(39), 27776-27785 (1999).

    5. Contos, J.J.A., and Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267, 243-253 (2001).

    Product Citations

    Sinderewicz, E., Grycmacher, K., Boruszewska, D., et al. Expression of factors involved in apoptosis and cell survival is correlated with enzymes synthesizing lysophosphatidic acid and its receptors in granulosa cells originating from different types of bovine ovarian follicles. Reprod. Biol. Endocrinol. 15(1), 72 (2017).