A selective sEH inhibitor
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N,N'-Dicyclohexylurea

Item No. 10004971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-dicyclohexyl-urea
CAS Number
2387-23-7
Synonyms
  • DCU
  • NSC 17013
Molecular Formula
C13H24N2O
Formula Weight
224.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
O=C(NC1CCCCC1)NC2CCCCC2
InChi Code
InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)
InChi Key
ADFXKUOMJKEIND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $22

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    25 g

    $36

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    Product Description

    N,N’ Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively.1 At 10 µM, DCU blocks the hydrolysis of cis- and trans-EETs by rat red blood cells and porcine coronary endothelial cells as well as completely inhibits 14,(15)-EET-induced PPARα activation.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morisseau, C., Goodrow, M.H., Dowdy, D., et al. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc. Natl. Acad. Sci. USA 96, 8849-8854 (1999).

    2. Jiang, H., Zhu, A.G., Mamczur, M., et al. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. J. Pharmacol. Exp. Ther. 326, 330-337 (2008).

    3. Fang, X., Kaduce, T.L., Weintraub, N.L., et al. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. The Journal of Biological Chemisty 276(18), 14867-14874 (2001).

    4. Fang, X., Hu, S., Xu, B., et al. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-α. Am. J. Physiol. Heart Circ. Physiol. 290, H55-H63 (2006).