A potent, selective 20-HETE synthase inhibitor
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CAY10434

Item No. 10005067

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine
CAS Number
769917-29-5
Molecular Formula
C17H25N3O
Formula Weight
287.4
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMf:PBS (pH 7.2)(1:3): .2 mg/mlDMSO: 12 mg/mlEthanol: 15 mg/ml
λmax
203, 242 nm
SMILES
CN(C)CCCCCCOC1=CC=C(N2C=CN=C2)C=C1
InChi Code
InChI=1S/C17H25N3O/c1-19(2)12-5-3-4-6-14-21-17-9-7-16(8-10-17)20-13-11-18-15-20/h7-11,13,15H,3-6,12,14H2,1-2H3
InChi Key
FIFQJYUSSPRJIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $118

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    10 mg

    $205

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    50 mg

    $888

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    Product Description

    CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 value of 8.8 nM when tested in human renal microsomes.1 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor. Bioorg. Med. Chem. Lett. 14, 333-336 (2004).