A fluorescent substrate for AEA transport
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CAY10455

Item No. 10005072

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]-2-[[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]amino]ethyl ester carbamic acid
CAS Number
290374-09-3
Synonyms
  • SKM 4-45-1
Molecular Formula
C47H52N2O10
Formula Weight
804.9
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/mlEthanol:PBS (pH 7.2)(1:1): .5 mg/ml
λmax
226, 291 nm
SMILES
CC(OC1=CC=C(C2(C(C=CC(NC(OCCNC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)=O)=C3)=C3C(O2)=O)C(C=CC(OC(C)=O)=C4)=C4O5)C5=C1)=O
InChi Code
InChI=1S/C47H52N2O10/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-44(52)48-28-29-55-46(54)49-35-22-25-39-38(30-35)45(53)59-47(39)40-26-23-36(56-33(2)50)31-42(40)58-43-32-37(57-34(3)51)24-27-41(43)47/h8-9,11-12,14-15,17-18,22-27,30-32H,4-7,10,13
InChi Key
LQMHXQGEEUIVLB-GKFVBPDJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $63

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    500 µg

    $274

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    1 mg

    $481

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    Product Description

    CAY10455 is a labeled analog of arachidonoyl ethanolamide (anandamide; AEA) that is non-fluorescent when outside the cell. Upon transport into the cell interior, it is cleaved by esterases to give a bright fluorescence at 530 nm.1 CAY10455 uptake into C6 glioma cells is inhibited by AEA and its analogs, and conversely CAY10455 inhibits the uptake of tritiated AEA, indicating that they compete for the AEA transporter.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muthian, S., Nithipatikom, K., Campbell, W.B., et al. Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. J. Pharmacol. Exp. Ther. 293, 289-295 (2000).