Suppressor of HIF-1α levels in cancer cells
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PX-478

Item No. 10005189

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride
CAS Number
685898-44-6
Molecular Formula
C13H18Cl2N2O3 • 2HCl
Formula Weight
394.1
Purity
≥90%
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
209, 253, 301 nm
SMILES
NC(C(O)=O)CC1=CC=C([N+](CCCl)(CCCl)[O-])C=C1
InChi Code
InChI=1S/C13H18Cl2N2O3/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)
InChi Key
GSKQMLGAUOTSKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $64

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    10 mg

    $103

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    25 mg

    $224

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    50 mg

    $383

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    Cayman Chemical
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    Product Description

    PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.1 It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.1 PX-478 can also increase chemo- or radiosensitivity of tumors.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Welsh, S., Williams, R., Kirkpatrick, L., et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α. Mol. Cancer Ther. 3(3), 233-244 (2004).

    2. Schwartz, D.L., Bankson, J.A., Lemos, R., Jr., et al. Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol. Cancer Ther. 9(7), 2057-2067 (2010).

    3. Zhao, T., Ren, H., Jia, L., et al. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget 6(4), 2250-2262 (2015).