A small molecule inducer of apoptosis
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2,3-DCPE (hydrochloride)

Item No. 10005229

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(2,3-dichlorophenoxy)propyl]amino]-ethanol, monohydrochloride
CAS Number
1009555-55-8
Molecular Formula
C11H15Cl2NO2 • HCl
Formula Weight
300.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
ClC1=C(Cl)C(OCCCN([H])CCO)=CC=C1.Cl
InChi Code
InChI=1S/C11H15Cl2NO2.ClH/c12-9-3-1-4-10(11(9)13)16-8-2-5-14-6-7-15;/h1,3-4,14-15H,2,5-8H2;1H
InChi Key
GFCJFYSIPRIHKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    50 mg

    $312

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    Cayman Chemical
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    Product Description

    2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 µM) more effectively than in normal human fibroblasts (IC50 = 12.6 µM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction.1 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, S., Zhu, H., Gu, J., et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64(3), 1110-1113 (2004).

    2. Zhu, H., Zhang, L., Wu, S., et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. Oncogene 23(29), 4984-4992 (2004).