An anorexigenic inhibitor of fatty acid synthase (FASN)
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(±)-C75

Item No. 10005270

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrahydro-4-methylene-2R-octyl-5-oxo-3S-furancarboxylic acid
CAS Number
191282-48-1
Molecular Formula
C14H22O4
Formula Weight
254.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
207 nm
SMILES
CCCCCCCC[C@H]1OC(=O)C(=C)C1C(=O)O
InChi Code
InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12?/m1/s1
InChi Key
VCWLZDVWHQVAJU-JHJMLUEUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $61

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    5 mg

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    10 mg

    $242

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    Product Description

    (±)-C75 is a stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.1 (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288(5475), 2379-2381 (2000).

    2. Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res. 60, 213-218 (2000).

    Product Citations

    Lin, D.T.S., and Conibear, E. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Elife 4, e11306 (2015).