An important decarboxylation cofactor and antioxidant
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DL-α-Lipoic Acid

Item No. 10005728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dithiolane-3-pentanoic acid
CAS Number
1077-28-7
Synonyms
  • Thioctic Acid
Molecular Formula
C8H14O2S2
Formula Weight
206.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:8): .25 mg/ml
λmax
203, 333 nm
SMILES
OC(=O)CCCCC1SSCC1
InChi Code
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChi Key
AGBQKNBQESQNJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $13

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    5 g

    $44

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    10 g

    $77

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    25 g

    $167

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    Product Description

    DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.1,2,3 DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29(3), 315-331 (1997).

    2. Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab. Rev. 14(4), 263-283 (1998).

    3. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy. Drug Metab. Rev. 29(4), 1025-1054 (1997).