A derivative of pravastatin
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NO-Pravastatin

Item No. 10006044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid, 4-(nitrooxy)butyl ester
CAS Number
733034-46-3
Synonyms
  • NCX 6550
Molecular Formula
C27H43NO10
Formula Weight
541.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2)(1:1): 0.5 mg/ml
λmax
237 nm
SMILES
O[C@H]1C[C@H](OC([C@H](CC)C)=O)[C@]2(C(C=C[C@@H]([C@@H]2CC[C@H](C[C@H](CC(OCCCCO[N+]([O-])=O)=O)O)O)C)=C1)[H]
InChi Code
InChI=1S/C27H43NO10/c1-4-17(2)27(33)38-24-15-21(30)13-19-8-7-18(3)23(26(19)24)10-9-20(29)14-22(31)16-25(32)36-11-5-6-12-37-28(34)35/h7-8,13,17-18,20-24,26,29-31H,4-6,9-12,14-16H2,1-3H3/t17-,18-,20+,21+,22+,23-,24-,26-/m0/s1
InChi Key
BYXWQFNMLQKHSM-DCOASORXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $25

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    5 mg

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    10 mg

    $113

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    50 mg

    $500

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    Product Description

    NO-pravastatin is a derivative of pravastatin (Item No. 10010343) that contains a nitric oxide-releasing moiety.1,2 It induces cGMP formation in PC12 cells (EC50 = 2.3 µM) and inhibits the proliferation of isolated rat aortic smooth muscle cells (IC50 = 2.2 µM).1 NO-pravastatin reduces inducible nitric oxide synthase (iNOS) and COX-2 levels in LPS-stimulated RAW 264.7 cells. NO-pravastatin (48.5 mg/kg) reduces splenocyte adhesion to artery segments isolated from wild-type and ApoE-/- mice.2 It reduces infarct size in a mouse model of myocardial infarction when administered at a dose of 22.4 µmol/kg.3 NO-pravastatin (24-48 mg/kg) reduces platelet consumption, lung vessel occlusion, and mortality in mouse models of platelet pulmonary thromboembolism induced by collagen and epinephrine or U-46619 (Item No. 16450).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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