A COX-2 inhibitor
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Valdecoxib

Item No. 10006120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide
CAS Number
181695-72-7
Synonyms
  • SC-65872
Molecular Formula
C16H14N2O3S
Formula Weight
314.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:8): 0.5 mg/mlEthanol: 5 mg/ml
λmax
202, 235 nm
SMILES
CC1=C(C2=CC=C(S(N)(=O)=O)C=C2)C(C3=CC=CC=C3)=NO1
InChi Code
InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
InChi Key
LNPDTQAFDNKSHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $80

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    10 mg

    $142

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    25 mg

    $332

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    50 mg

    $622

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    Product Description

    Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM for human recombinant COX-2 and COX-1, respectively).1 It decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated human whole blood (IC50 = 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Talley, J.J., Brown, D.L., Carter, J.S., et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2. J. Med. Chem. 43(5), 775-777 (2000).