Hepatoprotective flavonoid and 5-LO inhibitor
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Isomer(s)
34658Silychristin
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Silybin

Item No. 10006211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R)-2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CAS Number
22888-70-6
Synonyms
  • Silibinin
  • Silibinin A
  • Silybin A
Molecular Formula
C25H22O10
Formula Weight
482.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:9): .5 mg/mlDMSO: 10 mg/mlEthanol: .1 mg/ml
λmax
229, 288 nm
SMILES
OC1=CC(O)=CC(O[C@H](C2=CC3=C(O[C@H](CO)[C@@H](C4=CC(OC)=C(O)C=C4)O3)C=C2)[C@H]5O)=C1C5=O
InChi Code
InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1
InChi Key
SEBFKMXJBCUCAI-HKTJVKLFSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $19

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    5 g

    $68

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    10 g

    $123

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    50 g

    $481

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    Product Description

    Silybin is the major flavonolignan found in milk thistle (S. marianum).1 It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).2 Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 23(4), 749-754 (1996).

    2. Kim, J.Y., Kim, J.Y., Jenis, J., et al. Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg. Med. Chem. 27(12), 2499-2507 (2019).

    3. Trouillas, P., Marsal, P., Svobodová, A., et al. Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: A joint experimental and theoretical study. J. Phys. Chem. A 112(5), 1054-1063 (2008).