Active • Host: HEK293 cells • AA: 67-406 • MW: 40 kDa
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Renin (human, recombinant)

Item No. 10006217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Angiotensinogenase
Purity
≥85% estimated by SDS-PAGE
Source
Active recombinant human renin expressed in HEK293 cells
Amino Acids
67-406 (full length mature protein)
MW
40 kDa
Formulation (Request formulation change)
50 mM Tris, pH 8.0, with 150 mM NaCl and 5% glycerol
UniProt Accession №
P00797
Shipping & Storage Information
Storage
-80°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $423

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    Product Description

    Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.1 It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the juxtaglomerular cells in the kidney, by proteolytic removal of its autoinhibitory domain.2,3 Renin catalyzes the conversion of angiotensinogen to angiotensin I, which is the first and rate-limiting step of the renin-angiotensin system (RAS) responsible for regulating blood pressure.3 When blood pressure is low, renin secretion is increased and the RAS is activated, which increases arterial vasoconstriction and sodium resorption to maintain blood pressure at homeostatic levels.4 Deletion or substitution of the leucine in position 16 of REN, the gene encoding renin, that reduce or eliminate renin biosynthesis are associated with multiple inflammatory diseases, including chronic kidney failure and early-onset hyperuricemia.5 Cayman's Renin (human, recombinant) protein can be used for enzyme assay and Western blot applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mukoyama, M., and Nakao, K. Hormones of the kidney. Endocrinology 353-365 (2005).

    2. Persson, P.B. Renin: Origin, secretion and synthesis. J. Physiol. 552(Pt 3), 667-671 (2003).

    3. Patel, S., Rauf, A., Khan, H., et al. Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies. Biomed. Pharmacother. 94, 317-325 (2017).

    4. Cartledge, S., and Lawson, N. Aldosterone and renin measurements. Ann. Clin. Biochem. 37(Pt 3), 262-278 (2000).

    5. Zivná, M., Hůlková, H., Matignon, M., et al. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am. J. Hum. Genet. 85(2), 204-213 (2009).

    Product Citations

    Burdman, I., and Burckhardt, B.B. A concept to make low-abundance endogenous renin accessible to mass spectrometry: A multistep experimental design approach. J. Chromatogr. B 1134-1135:121856, (2019).