A convenient, 96-well format to measure human renin inhibitors
Features
  • Screen for inhibitors of renin aspartyl protease activity
  • Assay 45 samples in duplicate
  • Plate-based fluorometric measurement (ex 335-345 nm, em 484-510 nm)
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Renin Inhibitor Screening Assay Kit

Item No. 10006270

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $539

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    Product Description

    Cayman’s Renin Inhibitor Screening Assay Kit provides a convenient assay in a 96-well format for evaluating human renin inhibitors. The assay utilizes a renin-based synthetic peptide substrate which incorporates the fluorophore EDANS at one end and an EDAN-quenching molecule (Dabcyl) at the other end.1 After cleavage by renin, the peptide-EDANS product is released yielding bright fluorescence which can be easily analyzed using excitation wavelengths of 335-345 nm and emission wavelengths of 485-510 nm. The assay kit includes recombinant human renin (sufficient for 100 reactions), substrate, buffers, and complete instructions.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, G.T., Chung, C.C., Holzman, T.F., et al. A continuous fluorescence assay of renin activity. Anal. Biochem. 210, 351-359 (1993).

    Product Citations

    Syed, A.A., Lahiri, S., Mohan, D., et al. Cardioprotective effect of Ulmus wallichiana planchon in β-adrenergic agonist induced cardiac hypertrophy. Front. Pharmacol. 7:510, (2016).