A potent TRPV1 antagonist
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BCTC

Item No. 10006309

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
CAS Number
393514-24-4
Molecular Formula
C20H25ClN4O
Formula Weight
372.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 12.5 mg/mlEthanol: 10 mg/ml
λmax
247 nm
SMILES
ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2
InChi Code
InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
InChi Key
ROGUAPYLUCHQGK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $46

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    10 mg

    $86

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    50 mg

    $355

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    Product Description

    BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Valenzano, K.J., Grant, E.R., Wu, G., et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. J. Pharmacol. Exp. Ther. 306(1), 377-386 (2003).

    2. Gavva, N.R., Tamir, R., Klionsky, L., et al. Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol. Pharmacol. 68(6), 1524-1533 (2005).