The major pre-menopausal bioactive estrogen and an active metabolite of testosterone
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17β-Estradiol

Item No. 10006315

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
estra-1,3,5(10)-triene-3,17β-diol
CAS Number
50-28-2
Synonyms
  • E2
  • Estradiol
  • β-Estradiol
  • 17β-Oestradiol
Molecular Formula
C18H24O2
Formula Weight
272.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:4): 0.2 mg/mlEthanol: 2.5 mg/ml
λmax
203, 281 nm
SMILES
O[C@H]1CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=C3C=CC(O)=C4
InChi Code
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChi Key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $28

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    1 g

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    5 g

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    10 g

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    Product Description

    17β-Estradiol is the major pre-menopausal bioactive estrogen and an active metabolite of testosterone.1,2,3 It is produced primarily by the ovary, and to a lesser extent, by the adrenals, testes, and adipose tissue, as well as by the placenta during pregnancy.1 17β-Estradiol binds to estrogen receptors localized to the nucleus, cytoplasm, and plasma membrane and induces gene transcription or non-genomic intracellular signaling in a location-dependent manner.2 It regulates reproductive development in females and spermatogenesis in males, as well as various non-reproductive processes including lipid and glucose homeostasis, bone mass maintenance, cognition, energy balance, and dilation of blood vessels.2,3 17β-Estradiol deficiency due to hypogonadism or 17α-hydroxylase/17,20-lyase deficiency is associated with fatigue, incontinence, osteoporosis, depression, emotional instability, and hot flashes. Formulations containing 17β-estradiol have been used in the treatment of menopause symptoms and the prevention of osteoporosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahboobifard, F., Pourgholami, M.H., Jorjani, M., et al. Estrogen as a key regulator of energy homeostasis and metabolic health. Biomed. Pharmacother. 156, 113808 (2022).

    2. Kumar, A., Banerjee, A., Sigh, D., et al. Estradiol: A steroid with multiple facets. Horm. Metab. Res. 50(5), 359-374 (2018).

    3. Sabah-Negah, S., Hajali, V., Moradi, H.R., et al. The impact of estradiol on neurogenesis and cognitive functions in Alzheimer’s disease. Cell Mol. Neurobiol. 40(3), 283-299 (2019).

    Product Citations

    Zhang, Z., Qin, P., Deng, Y., et al. The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation. J. Neuroinflammation 15(1), 206 (2018).