A synthetic estrogen
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Quinestrol

Item No. 10006320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-17α-ol
CAS Number
152-43-2
Synonyms
  • Ethynyl Estradiol-3-cyclopentyl ether
  • W 3566
Molecular Formula
C25H32O2
Formula Weight
364.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
202, 281 nm
SMILES
C[C@@]12[C@@]([H])(CC[C@@]2(O)C#C)[C@]([C@]3([H])CC1)([H])CCC4=C3C=CC(OC5CCCC5)=C4
InChi Code
InChI=1S/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1
InChi Key
PWZUUYSISTUNDW-VAFBSOEGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $40

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    250 mg

    $93

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    500 mg

    $171

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    1 g

    $302

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    Product Description

    Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.1,2 It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baumgardner, S.B., Condrea, H., Daane, T.A., et al. Replacement estrogen therapy for menopausal vasomotor flushes. Comparison of Quinestrol and conjugated estrogens. Obstet. Gynecol. 51(4), 445-452 (1978).

    2. Skouby, S.O. Criteria for the selection of an optimal estrogen replacement. Gynecological Endocrinology 15, 60-67 (2001).