A synthetic catalase/SOD mimic and hydrogen peroxide scavenger
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EUK 134

Item No. 10006329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese
CAS Number
81065-76-1
Molecular Formula
C18H18ClMnN2O4
Formula Weight
416.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): .2 mg/ml
λmax
234, 328 nm
SMILES
[Cl-][Mn+3]12([N]3=CC4=CC=CC(OC)=C4[O-]2)[N](CC3)=CC5=CC=CC(OC)=C5[O-]1
InChi Code
InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3/b19-11+,20-12+;;
InChi Key
YUZJJFWCXJDFOQ-GAMUHHASSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $42

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    10 mg

    $71

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    50 mg

    $262

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    100 mg

    $481

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    Product Description

    EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro.1 EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284(1), 215-221 (1998).

    2. Rong, Y., Doctrow, S.R., Tocco, G., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Natl. Acad. Sci. USA 96, 9897-9902 (1999).