A urinary metabolite of thromboxane B1
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2,3-dinor Thromboxane B1

Item No. 10006330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11,15S-trihydroxy-2,3-dinor-thromba-13E-en-1-oic acid
CAS Number
196493-76-2
Synonyms
  • 2,3-dinor TXB1
Molecular Formula
C18H32O6
Formula Weight
344.4
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 20 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): .15 mg/ml
SMILES
O[C@@H]1[C@H](CCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
InChi Code
InChI=1S/C18H32O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h10-11,13-16,18-20,23H,2-9,12H2,1H3,(H,21,22)/b11-10+/t13-,14-,15-,16+,18?/m0/s1
InChi Key
LGWCOUWMTAQMQT-QCBHMXSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

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    Product Description

    In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.1,2 However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.1 In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).1 Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiabrando, C., Corada, M., Bachi, A., et al. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. Prostaglandins 47, 409-422 (1994).

    2. Westlund, P., Kumlin, M., Nordenström, A., et al. Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. Prostaglandins 31(3), 413-443 (1986).