An internal standard for the quantification of 14(15)-EET
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(±)14(15)-EET-d11

Item No. 10006410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-(14S,15R)-epoxy-5Z,8Z,11Z-eicosatrienoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
Synonyms
  • (±)14,15-EET-d11
  • (±)14,15-EpETrE-d11
Molecular Formula
C20H21D11O3
Formula Weight
331.5
Purity
≥99% deuterated forms (d1-d11)
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
[2H]C(C([2H])([2H])[2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\CCCC(O)=O.[2H]C(C([2H])([2H])[2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[C@H]2[C@H](O2)C/C=C\C/C=C\C/C=C\CCCC(O)=O
InChi Code
InChI=1S/2C20H32O3/c2*1-2-3-12-15-18-19(23-18)16-13-10-8-6-4-5-7-9-11-14-17-20(21)22/h2*4,6-7,9-10,13,18-19H,2-3,5,8,11-12,14-17H2,1H3,(H,21,22)/b2*6-4-,9-7-,13-10-/t2*18-,19+/m10/s1/i2*1D3,2D2,3D2,12D2,15D2
InChi Key
ZSUOIKQUEGJWDL-LCLWVSOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

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    Product Description

    (±)14(15)-EET-d11 is intended for use as an internal standard for the quantification of (±)14(15)-EET (Item No. 50651) by GC- or LC-MS. 14(S),15(R)-EET and 14(R),15(S)-EET are formed via epoxidation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by a variety of cytochrome P450 (CYP) isoforms.1 14(S),15(R)-EET is produced at a higher proportion by CYP2C23, whereas 14(R),15(S)-EET is produced at a greater proportion by CYP2B2 and CYP2C24.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Capdevila, J.H., Falck, J.R., and Harris, R.C. Cytochrome P450 and arachidonic acid bioactivation: Molecular and functional properties of the arachidonate monooxygenase. J. Lipid Res. 41(2), 163-181 (2000).

    Product Citations

    Cheng, D., Zinker, B.A., Luo, Y., et al. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity. Cell Metab. 34(11), 1732-1748 (2022).