A spin trap for superoxide radical detection
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DEPMPO

Item No. 10006435

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-(3,4-dihydro-2-methyl-1-oxido-2H-pyrrol-2-yl)-phosphonic acid, diethyl ester
CAS Number
157230-67-6
Synonyms
  • 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
Molecular Formula
C9H18NO4P
Formula Weight
235.2
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: miscibleDMSO: miscibleEthanol: misciblePBS (pH 7.2): miscible
λmax
240 nm
SMILES
[O-][N+]1=CCCC1(P(OCC)(OCC)=O)C
InChi Code
InChI=1S/C9H18NO4P/c1-4-13-15(12,14-5-2)9(3)7-6-8-10(9)11/h8H,4-7H2,1-3H3
InChi Key
OKCDBZSDRSXFIB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $134

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    250 mg

    $565

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    500 mg

    $1,058

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    Product Description

    DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide.1,2,3 DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO (Item No. 10006436).3 A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2•- does not produce the OH• adduct, which can be a drawback when using DMPO.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, N., Wilmont, C.M., Rosen, G.M., et al. Spin traps: In vitro toxicity and stability of radical adducts. Free Radic. Biol. Med. 34(11), 1473-1481 (2003).

    2. Anzai, K., Aikawa, T., Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. Arch. Biochem. Biophys. 415(2), 251-256 (2003).

    3. Liu, K.J., Miyake, M., Panz, T., et al. Evaluation of DEPMPO as a spin trapping agent in biological systems. Free Radic. Biol. Med. 26(5-6), 714-721 (1999).