A potent, selective S1P1 receptor agonist
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SEW2871

Item No. 10006440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
CAS Number
256414-75-2
Molecular Formula
C20H10F6N2OS
Formula Weight
440.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 1 mg/mlEthanol: 5 mg/ml
λmax
242, 273 nm
SMILES
FC(F)(F)c1cccc(c1)c1noc(n1)c1cc(c2ccccc2)c(s1)C(F)(F)F
InChi Code
InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
InChi Key
OYMNPJXKQVTQTR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    50 mg

    $288

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    Product Description

    Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood.1 Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate.2 SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 1582(1-3), 72-80 (2002).

    2. Sanna, M.G., Liao, J., Jo, E., et al. Sphingosine 1-phosphate (S1P) receptor subtypes SIP1 and SIP3, respectively, regulate lymphocyte recirculation and heart rate. The Journal of Biological Chemisty 279(14), 13839-13848 (2004).