An antioxidant with anti-atherogenic activity
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CAY10487

Item No. 10006480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester
CAS Number
778624-05-8
Synonyms
  • 3,4-Dihydrocinnamic Acid (L-alanine methyl ester) amide
Molecular Formula
C13H15NO5
Formula Weight
265.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:5): .35 mg/ml
λmax
220, 242, 297, 325 nm
SMILES
COC(=O)[C@H](C)NC(=O)\C=C/c1ccc(O)c(O)c1
InChi Code
InChI=1S/C13H15NO5/c1-8(13(18)19-2)14-12(17)6-4-9-3-5-10(15)11(16)7-9/h3-8,15-16H,1-2H3,(H,14,17)/b6-4+/t8-/m0/s1
InChi Key
WFBBISJLIGYSGF-JQTRYQTASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $53

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    25 mg

    $125

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    50 mg

    $220

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    Product Description

    CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity.1,2 The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.1 CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, S., Lee, C.H., Oh, J.H., et al. Anti-atherogenic effects of 3,4-dihydroxy hydrocinnamides. Bioorg. Med. Chem. Lett. 13, 2681-2682 (2003).

    2. Lee, S., Han, J.M., Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg. Med. Chem. Lett. 14(18), 4677-4681 (2004).