A potent, selective aryl hydrocarbon receptor antagonist
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CAY10464

Item No. 10006545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number
688348-37-0
Molecular Formula
C15H12Cl2O
Formula Weight
279.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:1): .5 mg/mlEthanol: 10 mg/ml
λmax
212, 326 nm
SMILES
COc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1
InChi Code
InChI=1S/C15H12Cl2O/c1-18-15-6-4-11(5-7-15)2-3-12-8-13(16)10-14(17)9-12/h2-10H,1H3/b3-2+
InChi Key
YDVZIQMQLZBUKX-NSCUHMNNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $25

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    25 mg

    $55

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    50 mg

    $105

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    100 mg

    $184

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    Product Description

    CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations.1 It is inactive as an estrogen receptor ligands even at 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Medina, P., Casper, R., Savouret, J.-F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J. Med. Chem. 48(1), 287-291 (2005).