Methyl ester of an intermediate in the synthesis of arachidonic acid
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Dihomo-γ-Linolenic Acid methyl ester

Item No. 10006580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8Z,11Z,14Z-eicosatrienoic acid, methyl ester
CAS Number
21061-10-9
Synonyms
  • SFE 21:3
  • Methyl DGLA
Molecular Formula
C21H36O2
Formula Weight
320.5
Purity
≥98%
Formulation (Request formulation change)
A 100 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: 1 mg/mlDMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): .15 mg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(OC)=O
InChi Code
InChI=1S/C21H36O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(22)23-2/h7-8,10-11,13-14H,3-6,9,12,15-20H2,1-2H3/b8-7-,11-10-,14-13-
InChi Key
QHATYOWJCAQINT-JPFHKJGASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $29

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    50 mg

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    100 mg

    $159

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    Product Description

    Dihomo-γ-linolenic acid (DGLA) is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Methyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as a possible treatment for various inflammatory disorders.1,2 Evening primrose oil is a DGLA-rich nutraceutical which has been advocated for such uses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schalin-Karrila, M., Mattila, L., Jansen, C.T., et al. Evening primrose oil in the treatment of atopic eczema: Effect on clinical status, plasma phospholipid fatty acids, and circulating blood prostaglandins. Br. J. Dermatol. 117, 11-19 (1987).

    2. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).