The dihomo-γ-linolenic acid metabolite of COX/TXA synthase
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Thromboxane B1

Item No. 10006610

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,11,15-trihydroxy-thrombox-13-en-1-oic acid
CAS Number
64626-32-0
Synonyms
  • TXB1
Molecular Formula
C20H36O6
Formula Weight
372.5
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlMethyl Acetate: 10 mg/mlPBS (pH 7.2): .15 mg/ml
SMILES
O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
InChi Code
InChI=1S/C20H36O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h12-13,15-18,20-22,25H,2-11,14H2,1H3,(H,23,24)/b13-12+/t15-,16-,17-,18+,20?/m0/s1
InChi Key
JSDWWNLTJCCSAV-VZBVYBAISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

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    Product Description

    TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase.1 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.1 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manku, M.S., Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol. Prostaglandins Med. 3(2), 119-128 (1979).