A non-selective COX inhibitor
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Labeled Version(s)
28148(±)-Ketoprofen-d3
Metabolite(s)
27180(±)-Ketoprofen Glucuronide
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(±)-Ketoprofen

Item No. 10006661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-benzoyl-α-methyl-benzeneacetic acid
CAS Number
22071-15-4
Synonyms
  • (R,S)-Ketoprofen
  • 2-(3-benzoylphenyl)Propionic Acid
Molecular Formula
C16H14O3
Formula Weight
254.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): .5 mg/ml
λmax
254 nm
SMILES
O=C(C1=CC=CC=C1)C2=CC=CC(C(C)C(O)=O)=C2
InChi Code
InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
InChi Key
DKYWVDODHFEZIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 µM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant.2 Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. Zhang, J., Xu, X., Zhu, L., et al. Preparation and pre-clinical characterization of sustained release ketoprofen implants for the management of pain and inflammation in osteoarthritis. Trop. J. Pharm. Res. 17(4), 577-582 (2018).