A thioester phospholipase substrate
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HEPC

Item No. 10006695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-thia-4-phosphatetracosan-1-aminium, 4-oxide, inner salt
CAS Number
60793-01-3
Synonyms
  • 2-Hexadecanoylthio-1-Ethylphosphorylcholine
Molecular Formula
C23H48NO5PS
Formula Weight
481.7
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 30 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CCCCCCCCCCCCCCCC(SCCOP([O-])(OCC[N+](C)(C)C)=O)=O
InChi Code
InChI=1S/C23H48NO5PS/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(25)31-22-21-29-30(26,27)28-20-19-24(2,3)4/h5-22H2,1-4H3
InChi Key
BDPQVGIMLZYZQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $173

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    10 mg

    $327

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    25 mg

    $770

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    50 mg

    $1,368

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    Product Description

    Thioester analogs of glycerophospholipids, in combination with Ellman’s reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC is a truncated analog of phosphatidylcholine with the entire sn-1 substituent deleted, and with a hexadecylthioester in the sn-2 position.1 HEPC is a substrate for Type II phospholipase A2 (PLA2) enzymes, such as porcine pancreatic, bee venom, and snake venom PLA2. The intrinsic biological activity of HEPC has not been actively investigated.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhat, M.K., Mueller-Harvey, I., Sumner, I.G., et al. Simplified methods for the synthesis of 2-hexadecanoylthio-1-ethylphosphorylcholine and for the determination of phospholipase A2 activity. Biochim. Biophys. Acta 1166(2-3), 244-250 (1993).