QNZ

Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.¹ QNZ is an inhibitor of NF-κB activation with an IC₅₀ of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC₅₀ of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.²

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1. Karin, M., Yamamtoto, Y., and Wang, Q.M. The IKK NF-κB system: A treasure trove for drug development. Nat. Rev. Drug Discov. 3(1), 17-26 (2004).

2. Tobe, M., Isobe, Y., Tomizawa, H., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorg. Med. Chem. 11(3), 383-391 (2003).