A highly purified enzyme preparation
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Prostaglandin D Synthase (lipocalin-type; human recombinant)

Item No. 10006788

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Lipocalin-PGDS
  • L-PGDS
Purity
≥85% estimated by SDS-PAGE
Source
Recombinant N-terminal GST-tagged enzyme purified from E. coli
MW
46 kDa/subunit
Formulation (Request formulation change)
50 mM sodium phosphate, pH 7.2, containing 20% glycerol, 150 mM sodium chloride, 1 mM DTT, and 0.5 mM EDTA
UniProt Accession №
P41222
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    250 µg

    $528

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    Product Description

    Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme and the hematopoietic enzyme.1,2,3 L-PGDS is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as β-trace, which is a major protein in human cerebrospinal fluid.1 Cayman’s L-PGDS (human recombinant) is a highly-purified GST-fusion protein isolated from an E. coli expression system. Cysteines 89 and 186 have been changed to alanines to prevent protein misfolding.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Urade, Y., Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. J. Lipid Mediat. Cell Signal. 12(2-3), 257-273 (1995).

    2. Urade, Y., and Hayaishi, O. Prostaglandin D synthase: Structure and function. Vitam. Horm. 58, 89-120 (2000).

    3. Urade, Y., and Eguchi, N. Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins Other Lipid Mediat. 68-69, 375-382 (2002).