A membrane-permeable antagonist of the inositol-1,4,5-triphosphate receptor
Related Products
Diastereomer(s)
64950Xestospongin C
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Araguspongin B

Item No. 10006797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1R-(1R*,4aR*,11S*,12aR*,13R*,16aR*,23S*,24aR*)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b’]dipyridine
CAS Number
123000-02-2
Molecular Formula
C28H50N2O2
Formula Weight
446.7
Purity
≥90%
Formulation
A clear film
SMILES
C1CCC[C@H]2CCCN3CC[C@H](CCCCCC[C@H]4CCCN5CC[C@@H](CC1)O[C@H]45)O[C@H]23
InChi Code
InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24-,25-,26+,27+,28+/m0/s1
InChi Key
PQYOPBRFUUEHRC-SCUYQTRWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

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    Product Description

    Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM.1 It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gafni, J., Munsch, J.A., Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19, 723-733 (1997).