A selective agonist of PPARδ
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Small Molecule Modulators
Receptor Pharmacology
Agonists

Research Area

GW 0742

Item No. 10006798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid
CAS Number
317318-84-6
Synonyms
  • GW 610742
Molecular Formula
C21H17F4NO3S2
Formula Weight
471.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF: PBS (pH 7.2)(1:10): 0.1 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
323 nm
SMILES
CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C(F)=C3)S2)=CC=C1OCC(O)=O
InChi Code
InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
InChi Key
HWVNEWGKWRGSRK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $392

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    50 mg

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    Product Description

    GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity. Bioorg. Med. Chem. Lett. 13(9), 1517-1521 (2003).

    2. Smith, S.A., Monteith, G.R., Robinson, J.A., et al. Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons. J. Neurosci. Res. 77(2), 240-249 (2004).

    Product Citations

    Wang, X., Wang, G., Shi, Y., et al. PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions. Oncogenesis 5, e232 (2016).