A selective iPLA2β inhibitor
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Labeled Version(s)
10535(S)-Bromoenol lactone-d7
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(S)-Bromoenol lactone

Item No. 10006801

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl)-2H-pyran-2-one
CAS Number
478288-94-7
Synonyms
  • (S)-BEL
Molecular Formula
C16H13BrO2
Formula Weight
317.2
Purity
≥98%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): .05 mg/ml
λmax
223, 280 nm
SMILES
Br/C=C1\CC[C@H](C(=O)O\1)c1cccc2ccccc12
InChi Code
InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+/t15-/m0/s1
InChi Key
BYUCSFWXCMTYOI-PABFRNLHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $63

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    5 mg

    $253

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    10 mg

    $402

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    Product Description

    (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.1 (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2) β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. The Journal of Biological Chemisty 277(36), 32807-32814 (2002).