A deuterated internal standard for a predominant isoprostane isomer
Related Products
Unlabeled Version(s)
163108,12-iso-iPF2α-VI
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

8,12-iso-iPF2α-VI-d11

Item No. 10006878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(12α)-5,9α,11α-trihydroxy-prosta-6E,14Z-dien-1-oic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
CAS Number
1616977-85-5
Synonyms
  • 8,12-iso-Isoprostane-F2α-VI-d11
  • 12-iso-5,6E,14Z-PGF2α-d11
  • 12-iso-5,6E,14Z-Prostaglandin F2α-d11
Molecular Formula
C20H23D11O5
Formula Weight
365.6
Purity
≥99% deuterated forms (d1-d11)
Formulation
A 50 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: >100mg/ml (PGF2 alpha)DMSO: >100mg/ml (PGF2 alpha)Ethanol: >100mg/ml (PGF2 alpha)PBS pH 7.2: 3 mg/ml (PGF2 alpha)
SMILES
OC(CCCC(O)=O)/C=C/[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@H](O)C[C@@H]1O
InChi Code
InChI=1S/C20H34O5/c1-2-3-4-5-6-7-10-16-17(19(23)14-18(16)22)13-12-15(21)9-8-11-20(24)25/h6-7,12-13,15-19,21-23H,2-5,8-11,14H2,1H3,(H,24,25)/b7-6-,13-12+/t15?,16-,17+,18+,19-/m0/s1/i1D3,2D2,3D2,4D2,5D2
InChi Key
RZCPXIZGLPAGEV-JVUJZTPFSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 µg

    $209

    Add

    25 µg

    $498

    Add

    50 µg

    $939

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    8,12-iso-isoprostane F2α-VI-d11 (8,12-iso-iPF2α-VI-d11) contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8,12-iso-iPF2α-VI by GC- or LC-mass spectrometry. The relative abundance of deuterium atoms incorporated into each molecule has not been determined. Cayman certifies that less that 1% of the product has no deuterium incorporation (<1% d0). Isoprostanes are non-enzymatic, non-cyclooxygenase prostanoid products of peroxidative damage to membrane lipids.1 Among the many isoprostane isomers, 8,12-iso-iPF2α-VI has been demonstrated to be one of the predominant isomers formed and is also present in urine as one of the major isoprostane products.2 8,12-iso-iPF2α-VI-d11 is a deuterated internal standard for use in isoprostane quantitation by mass spec modalities. The compound is diastereomeric at C-5, but is otherwise an optically active, single enantiomer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Diaz, M.N., Frei, B., Vita, J.A., et al. Antoixidants and atherosclerotic heart disease. New Engl. J. Med. 337(6), 408-416 (1997).

    2. Lawson, J.A., Li, H., Rokach, J., et al. Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F2α-VI, in human urine. The Journal of Biological Chemisty 273(45), 29295-29301 (1998).