A well-characterized nitroxy (HNO) donor
Related Products
Isomer(s)
33451Sulfanilic Acid
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Piloty’s Acid

Item No. 10006995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-benzenesulfonamide
CAS Number
599-71-3
Synonyms
  • Benzenesulphonydroxamic Acid
Molecular Formula
C6H7NO3S
Formula Weight
173.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH7.2): 2 mg/ml
λmax
219 nm
SMILES
ON([H])S(C1=CC=CC=C1)(=O)=O
InChi Code
InChI=1S/C6H7NO3S/c8-7-11(9,10)6-4-2-1-3-5-6/h1-5,7-8H
InChi Key
BRMDATNYMUMZLN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $17

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    1 g

    $28

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    5 g

    $82

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    10 g

    $135

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    Product Description

    Piloty’s acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty’s acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t½ = 5,500 minutes) making its use most effective above pH 8.0. The half-life of Piloty’s acid decreases with an increase in pH to 561, 90, and 33 minutes at pH 8.0, 9.0, and 10.0, respectively.1 Piloty’s acid also inhibits yeast aldehyde dehydrogenase with an IC50 of 48 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. hughes, M.N., and Cammack, R. Synthesis, chemistry, and application of nitroxyl ion releasers sodium trioxodinitrate or Angeli’s Salt and Piloty’s Acid. Methods Enzymol. 301, 279-287 (1999).

    2. Nagasawa, H.T., Kawle, S.P., Elberling, J.A., et al. Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis-à-vis vascular smooth muscle relaxants. J. Med. Chem. 38, 1865-1871 (1995).