A metabolite of EPA
Related Products
Parent Compound(s)
10173(±)14(15)-EpETE
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(±)14(15)-DiHETE

Item No. 10006998

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)14,15-dihydroxy-5Z,8Z,11Z,17Z-eicosatetraenoic acid
Synonyms
  • (±)14,15-dihydroxy-eicosa-5,8,11,17-Tetraenoic Acid
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): .5 mg/ml
SMILES
CC/C=C\C[C@@H](O)[C@H](O)C/C=C\C/C=C\C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h3-4,6-7,9-10,12-13,18-19,21-22H,2,5,8,11,14-17H2,1H3,(H,23,24)/b6-4-,9-7-,12-3-,13-10-/t18-,19-/m1/s1
InChi Key
BLWCDFIELVFRJY-YYXNPAPNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $116

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    50 µg

    $215

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    100 µg

    $406

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    Product Description

    (±)14(15)-DiHETE is an oxylipin and a metabolite of the ω-3 fatty acid eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908).1,2 It is formed via cytochrome P450-mediated epoxidation of EPA to (±)14(15)-EpETE (Item No. 10173), followed by conversion of the epoxide to a diol by soluble epoxide hydrolase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jónasdóttir, H.S., Ioan-Facsinay, A., Kwekkeboom, J., et al. An advanced LC–MS/MS platform for the analysis of specialized pro-resolving lipid mediators. Chromatographia 78(5-6), 391-401 (2014).

    2. Shearer, G.C., Harris, W.S., Pedersen, T.L., et al. Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters. J. Lipid. Res. 51(8), 2074-2081 (2010).

    Product Citations

    Brouwers, H., Jónasdóttir, H.S., Kuipers, M.E., et al. Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid. J. Immunol. 205(10), 2840-2849 (2020).