Combrestatin A4 (CAS 117048-59-6) | Cayman Chemical
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Combrestatin A4

Item № 10007412
CAS № 117048-59-6
Purity ≥98%
product image
                (CAS 117048-59-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $50.00 0.00
     10 mg $95.00 0.00
     25 mg $225.00 0.00
     50 mg $400.00 0.00

Pricing updated 2018-10-20. Prices are subject to change without notice.

Description
Synonyms
  • CA4
  • Combretastatin A4
  • CRC 87-09

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively.1 CA4 inhibits tubulin polymerization with an IC50 value of 2.2 µM.2

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Technical Information
Formal Name
2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol
CAS Number
117048-59-6
Synonyms
  • CA4
  • Combretastatin A4
  • CRC 87-09
Molecular Formula
C18H20O5
Formula Weight
316.4
Purity
≥98%
Formulation
A crystalline solid
λmax
222, 296 nm
SMILES
COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1OC
InChI Code
InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChI Key
HVXBOLULGPECHP-WAYWQWQTSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Research 24, 179-186 (2004).

2. Dey, P. Chromatin remodeling, cancer and chemotherapy. Current Medicinal Chemistry 13, 2909-2919 (2006).

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