A stearoyl CoA desaturase inhibitor
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10-Thiastearic Acid

Item No. 10007417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-(octylthio)-nonanoic acid
CAS Number
105099-89-6
Molecular Formula
C17H34O2S
Formula Weight
302.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.15 mg/ml
SMILES
CCCCCCCCSCCCCCCCCC(O)=O
InChi Code
InChI=1S/C17H34O2S/c1-2-3-4-5-9-12-15-20-16-13-10-7-6-8-11-14-17(18)19/h2-16H2,1H3,(H,18,19)
InChi Key
OMIBNTWPNMKIGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $46

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    10 mg

    $86

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    50 mg

    $355

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    100 mg

    $618

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    Product Description

    Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.1,2 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.3 This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochem. Pharmacol. 51(6), 751-758 (1996).

    2. Pascal, R.A., Jr., and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. J. Lipid Res. 27(2), 221-224 (1986).

    3. Hovik, K.E., Spydevold, O.S., and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochim. Biophys. Acta 1349(3), 251-256 (1997).