Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases
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L-Glutathione, reduced

Item No. 10007461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-L-cysteinyl-glycine
CAS Number
70-18-8
Synonyms
  • GSH
Molecular Formula
C10H17N3O6S
Formula Weight
307.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
H2O: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
SC[C@H](NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O
InChi Code
InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5?,6-/m0/s1
InChi Key
RWSXRVCMGQZWBV-GDVGLLTNSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $21

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    5 g

    $86

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    10 g

    $152

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    25 g

    $329

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    Product Description

    Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals.1,2 GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.2,3 GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status.4,5 The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Foyer, C.H., Lelandais, M., and Kunert, K.J. Photooxidative stress in plants. Physiol. Plant. 92, 696-717 (1994).

    2. Bedia, C. Glutathione: Metabolism and function. (1976).

    3. Baillie, T.A., and Slatter, J.G. Glutathione: A vehicle for the transport of chemically reactive metabolites in vivo. Acc. Chem. Res. 24, 264-270 (1991).

    4. Inoue, M., Saito, Y., Hirata, E., et al. Regulation of redox states of plasma proteins by metabolism and transport of glutathione and related compounds. J. Protein Chem. 6, 207-225 (1987).

    5. Inoue, M. Interorgan metabolism and membrane transport of glutathione and related compounds. Renal Biochemistry 225-269 (1985).