Pure inactive precursor of renin
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Prorenin (human, recombinant)

Item No. 10007599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Angiotensinogenase
  • Angiotensin forming enzyme
Purity
≥90% estimated by SDS-PAGE
Source
Recombinant enzyme expressed in HEK cells
Amino Acids
1-406 (full length)
MW
45 kDa
Formulation (Request formulation change)
50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 5% glycerol
UniProt Accession №
P00797
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $401

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    Product Description

    Prorenin is the inactive precursor of renin, which is a key enzyme in the regulation of blood pressure and electrolyte balance. In renal juxtaglomerular cells, sequential cleavage of the N-terminal 20 and 46 amino acids of preprorenin produces prorenin and active renin, respectively.1 Renin catalyzes the conversion of angiotensinogen to angiotensin I.2 Prorenin exhibits 5-10% of the proteolytic activity of renin, however, the blood circulating levels are 10 times higher.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holzman, T.F., Chung, C.C., Edalji, R., et al. Recombinant human prorenin from CHO cells: Expression and purification. J. Protein Chem. 9(6), 663-672 (1990).

    2. Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc. Natl. Acad. Sci. USA 80, 7405-7409 (1983).

    3. Sealey, J.E., Atlas, S.A., and Laragh, J.H. Prorenin and other large molecular weight forms of renin. Endocr. Rev. 1(4), 365-391 (1980).

    4. Heinrikson, R.L., Hui, J., Zürcher-Neely, H., et al. A structural model to explain the partial catalytic activity of human prorenin. Am. J. Hypertens. 2, 367-380 (1989).

    Product Citations

    Burdman, I., and Burckhardt, B.B. Human prorenin determination by hybrid immunocapture liquid chromatography-mass spectrometry: A mixed-solvent-triggered digestion utilizing D-optimal design. Rapid Commun. Mass Spectrom. e8932, (2020).