A synthetic phosphatidylinositol for signal transduction research
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PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

Item No. 10007764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(1,2-dioctanoylphosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt
Synonyms
  • DOPI-3,4,5-P3
  • Phosphatidylinositol-3,4,5-trisphosphate
  • PIP3[3',4',5'](8:0/8:0)
  • PI(3,4,5)P3 (8:0/8:0)
Molecular Formula
C25H46O22P4 • 4Na
Formula Weight
914.5
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
SMILES
O=C(OC[C@H](COP(O[C@@H]1[C@H](O)[C@H](O[P+]([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O])(O)=O)[C@H]1O)([O-])=O)OC(CCCCCCC)=O)CCCCCCC.[Na+].[Na].[Na+].[Na]
InChi Code
InChI=1S/C25H50O22P4.4Na/c1-3-5-7-9-11-13-18(26)41-15-17(43-19(27)14-12-10-8-6-4-2)16-42-51(39,40)47-22-20(28)23(44-48(30,31)32)25(46-50(36,37)38)24(21(22)29)45-49(33,34)35;;;;/h17,20-25,28-29H,3-16H2,1-2H3,(H,39,40)(H2,30,31,32)(H2,33,34,35)(H2,36,3
InChi Key
HKEJKRRMHQTDJY-JQCOAGCCSA-J
Side Chain Carbon Sum
16:0
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $66

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    500 µg

    $285

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    1 mg

    $503

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    Product Description

    PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The short fatty acid chains of this analog give it different physical properties including high solubility in aqueous media compared to naturally occurring PtdIns-(3,4,5)-P3. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Phosphorylation of PtdIns-(4,5)-P2 by phosphoinositide (PI)-3-kinase initiates an intricate signalling cascade at the fore front of scientific research.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat. Rev. Cancer 2(7), 489-501 (2002).