An inhibitor of Ca2+ activated chloride channels
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D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)

Item No. 10007782

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-myo-inositol-3,4,5,6-tetra(hydrogen phosphate), tetrasodium salt
Synonyms
  • Ins(3,4,5,6)-P4
  • 3,4,5,6-IP4
Molecular Formula
C6H12O18P4 • 4Na
Formula Weight
588.0
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
SMILES
O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C6H16O18P4.4Na/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;/q;4*+1/p-4/t1-,2+,3?,4?,5?,6?;;;;
InChi Key
DZJJWPAQUIBBLR-GUBBRYCUSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $149

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    500 µg

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    1 mg

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    Product Description

    D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM.1 Related inositol oligophosphates Ins(1,3,4,5)-P4, Ins(1,3,4,6)-P4, Ins(1,4,5,6)-P4, and Ins(1,3,4,5,6)-P5 do not inhibit the calcium channel at concentrations up to 100 µM.1 Ins(1,3,4)P3-mediated inhibition of Ins(3,4,5,6)-P4 1-kinase increases the cellular level of Ins(3,4,5,6)-P4, thus regulating channel inhibition.2 Ins(3,4,5,6)-P4 was found to be inactive when analyzed for Ca2+-releasing potency in Xenopus oocytes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, W., Kaetzel, M.A., Bruzik, K.S., et al. Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. The Journal of Biological Chemisty 271(24), 14092-14097 (1996).

    2. Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. The Journal of Biological Chemisty 274(27), 18973-18980 (1999).

    3. DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am. J. Physiol. 266(2 Pt 1), C429-C436 (1994).