An internal standard for the quantification of 13,14-dihydro-15-keto PGF2α
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13,14-dihydro-15-keto Prostaglandin F2α-d4

Item No. 10007793

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α-dihydroxy-15-oxo-prost-5Z-en-1-oic-3,3,4,4-d4 acid
CAS Number
42932-59-2
Synonyms
  • 13,14-dihydro-15-keto PGF2α-d4
  • PGFM-d4
Molecular Formula
C20H30D4O5
Formula Weight
358.5
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CCCCCC(CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)=O
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19-/m1/s1/i5D2,8D2
InChi Key
VKTIONYPMSCHQI-YFUTVRNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 µg

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    500 µg

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    Product Description

    13,14-dihydro-15-keto Prostaglandin F2α-d4 (13,14-dihydro-15-keto PGF2α-d4) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGF2α (Item No. 16670) by GC- or LC-MS. 13,14-dihydro-15-keto PGF2α is the first prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway.1 Measurement of 13,14-dihydro-15-keto PGF2α in plasma can be used as a marker of the in vivo production of PGF2α.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu. Rev. Biochem. 47, 997-1029 (1978).

    2. Del Vecchio, R.P., Maxey, K.M., and Lewis, G.S. A quantitative solid-phase enzymeimmunoassay for 13,14-dihydro-15-keto-prostaglandin F2α in plasma. Prostaglandins 43(4), 321-330 (1992).

    3. Meyer, H.H.D., Eisele, K., and Osaso, J. A biotin-streptavidin amplified enzyme immunoassay for 13,14-dihydro-15-keto-PGF2α. Prostaglandins 38(3), 375-383 (1989).

    Product Citations

    Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model. J. Clin. Invest. 130, 3670-3685 (2019).