Active, pure human recombinant enzyme
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Leukotriene A4 Hydrolase (human, recombinant)

Item No. 10007817

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • LTA4H
Purity
≥90% estimated by SDS-PAGE
Source
Active recombinant protein expressed in E. coli with C-terminal His-tag
Amino Acids
1-610
MW
~69 kDa
Formulation (Request formulation change)
100 mM Tris, pH 8.0, with 100 mM potassium chloride and 20% glycerol
UniProt Accession №
P09960
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $554

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    Product Description

    Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into LTB4, a potent neutrophil chemoattractant.1 In addition to the hydrolase activity, LTA4H also exhibits anion-dependent aminopeptidase activity.1,2 LTA4H is a potential new drug target for a variety of indications associated with leukocyte infiltration to sites of inflammation. Cayman’s LTA4H (human, recombinant) has been expressed and purified from E. coli. Both the epoxide hydrolase and aminopeptidase activities of the enzyme are functional as assessed by measurement of the separate enzyme activities. The enzyme therefore has application for the screening of inhibitors of LTB4 synthesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haeggström, J.Z. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. The Journal of Biological Chemisty 279(49), 50639-50642 (2004).

    2. Rudberg, P.C., Tholander, F., Andberg, M., et al. Leukotriene A4 hydrolase: Identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. The Journal of Biological Chemisty 279(26), 27376-27382 (2004).