5-Lipoxygenase (Phospho-Ser⁵²³) Polyclonal Antibody

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs).¹ Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis,² and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by protein kinase A (PKA) phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, may therefore contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser⁵²³ on 5-LO provides a valuable tool for studying the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis.

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1. Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294(5548), 1871-1875 (2001).

2. Wilborn, J., Bailie, M., Coffey, M., et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Invest. 97, 1827-1836 (1996).

Yoo, J.-M., Yang, J.-H., Kim, Y.S., et al. Inhibitory effect of Loranthus parasiticus on IgE-mediated allergic responses in RBL-2H3 cells. Mediators Inflamm. 2016, 8742562 (2016).